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Article

Androgen receptor represses the neuroendocrine transdifferentiation process in prostate cancer cells.

Molecular endocrinology (Baltimore, Md.) - 1 Sept 2003

Wright Michael E, Tsai Ming-Jer, Aebersold Ruedi

Abstract excerpt

Androgen-ablation therapy is an effective method for treating prostate cancer. However, prostate tumors that survive long-term androgen-ablation therapy are classified as androgen-independent as they proliferate in the absence of androgens, and they tend to be enriched for neuroendocrine (NE) cells. Androgen withdrawal causes androgen-dependent prostate cancer cells to adopt a pronounced NE phenotype, suggesting...

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PMID: 12775765
DOI: 10.1210/me.2003-0031

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