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Article

REST is a crucial regulator for acquiring EMT-like and stemness phenotypes in hormone-refractory prostate cancer.

Scientific reports - 3 Mar 2017

Chang Yi-Ting, Lin Tzu-Ping, Campbell Mel, Pan Chin-Chen, Lee Shu-Hui, Lee Hsin-Chen, Yang Muh-Hwa, Kung Hsing-Jien, Chang Pei-Ching

Abstract excerpt

Castration-resistance prostate cancer (CRPC), also known as hormone-refractory prostate cancer (HRPC), requires immediate attention since it is not only resistant to androgen ablation, chemo- and radiotherapy, but also highly metastatic. Increasing evidence suggests that enrichment of neuroendocrine (NE) cells is associated with CRPC. Here, combined RNA-seq and ChIP-seq analysis reveals that REST is involved in...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Epigenesis, Genetic

Share to Epithelial-Mesenchymal Transition

Share to Hyaluronan Receptors

Share to Prostatic Neoplasms, Castration-Resistant

Share to Sequence Analysis, RNA

Share to Twist-Related Protein 1

Source

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Identifiers

PMID: 28256535
DOI: 10.1038/srep42795
PMCID: PMC5335619

Genes

REST

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 5 Sept 2026. Manifest publication-graph-cohort-2026-09-05.1.

Source receipt: pubmed, retrieved 5 Sept 2026.

Related research

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REST is a crucial regulator for acquiring EMT-like and stemness phenotypes in hormone-refractory prostate cancer.PMID 28256535Read ↗

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RNA Splicing Factors SRRM3 and SRRM4 Distinguish Molecular Phenotypes of Castration-Resistant Neuroendocrine Prostate CancerSemantic proximity Read ↗

Molecular profiling stratifies diverse phenotypes of treatment-refractory metastatic castration-resistant prostate cancerSemantic proximity Read ↗

Androgen deprivation induces neuroendocrine phenotypes in prostate cancer cells through CREB1/EZH2-mediated downregulation of RESTSemantic proximity Read ↗

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