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Atypical Hemolytic Uremic Syndrome

23 Oct 2013

Abstract excerpt

Hemolytic uremic syndrome (HUS) is a triad of microangiopathic hemolytic anemia, thrombocytopenia, and acute renal failure. The atypical form of HUS is a disease characterized by complement overactivation. Inherited defects in complement genes and acquired autoantibodies against complement regulatory proteins have been described. Incomplete penetrance of mutations in all predisposing genes is reported, suggesting...

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PMID: 24161037
DOI: 10.1016/j.semnephrol.2013.08.003

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