Atypical hemolytic uremic syndrome, genetic basis, and clinical manifestations.

Abstract excerpt

Atypical hemolytic uremic syndrome (aHUS) is now well recognized to be a disease characterized by excessive complement activation in the microvasculature. In both the familial and sporadic forms, inherited and acquired abnormalities affecting components of the alternative complement pathway are found in ~ 60% of patients. These include mutations in the genes encoding both complement regulators (factor H, factor...

Topics

Share this publication in a Topic to start or enrich a Post.

• Share to Atypical Hemolytic Uremic Syndrome
• Share to Genetic Predisposition to Disease