Article
Atypical hemolytic uremic syndrome associated with mutations in complement regulator genes.
Seminars in thrombosis and hemostasis - 1 Sept 2010
Le Quintrec Moglie, Roumenina Lubka, Noris Marina, Frémeaux-Bacchi Véronique
Abstract excerpt
In the last 10 years the knowledge of the pathophysiology of atypical hemolytic uremic syndrome (aHUS) has substantially increased. Nevertheless, aHUS remains a severe disorder, in which early recognition of symptoms remains a key issue. The landmark discovery of genetic abnormalities in complement regulatory genes in most patients gave us new insights into the influence of each abnormality on the disease outcome...
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