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Article

Variation in chromatin accessibility in human kidney cancer links H3K36 methyltransferase loss with widespread RNA processing defects.

Genome research - 1 Feb 2014

Simon Jeremy M, Hacker Kathryn E, Singh Darshan, Brannon A Rose, Parker Joel S, Weiser Matthew, Ho Thai H, Kuan Pei-Fen, Jonasch Eric, Furey Terrence S, Prins Jan F, Lieb Jason D, Rathmell W Kimryn, Davis Ian J

Abstract excerpt

Comprehensive sequencing of human cancers has identified recurrent mutations in genes encoding chromatin regulatory proteins. For clear cell renal cell carcinoma (ccRCC), three of the five commonly mutated genes encode the chromatin regulators PBRM1, SETD2, and BAP1. How these mutations alter the chromatin landscape and transcriptional program in ccRCC or other cancers is not understood. Here, we identified...

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Share to Carcinoma, Renal Cell
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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Histone-Lysine N-Methyltransferase

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Source

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Identifiers

PMID: 24158655
DOI: 10.1101/gr.158253.113
PMCID: PMC3912414

Genes

SETD2
BAP1
PBRM1

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 5 Sept 2026. Manifest publication-graph-cohort-2026-09-05.1.

Source receipt: pubmed, retrieved 5 Sept 2026.

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