Article
Systematic sequencing of renal carcinoma reveals inactivation of histone modifying genes.
Nature - 21 Jan 2010
Dalgliesh Gillian L, Furge Kyle, Greenman Chris, Chen Lina, Bignell Graham, Butler Adam, Davies Helen, Edkins Sarah, Hardy Claire, Latimer Calli, Teague Jon, Andrews Jenny, Barthorpe Syd, Beare Dave, Buck Gemma, Campbell Peter J, Forbes Simon, Jia Mingming, Jones David, Knott Henry, Kok Chai Yin, Lau King Wai, Leroy Catherine, Lin Meng-Lay, McBride David J, Maddison Mark, Maguire Simon, McLay Kirsten, Menzies Andrew, Mironenko Tatiana, Mulderrig Lee, Mudie Laura, O'Meara Sarah, Pleasance Erin, Rajasingham Arjunan, Shepherd Rebecca, Smith Raffaella, Stebbings Lucy, Stephens Philip, Tang Gurpreet, Tarpey Patrick S, Turrell Kelly, Dykema Karl J, Khoo Sok Kean, Petillo David, Wondergem Bill, Anema John, Kahnoski Richard J, Teh Bin Tean, Stratton Michael R, Futreal P Andrew
Abstract excerpt
Clear cell renal cell carcinoma (ccRCC) is the most common form of adult kidney cancer, characterized by the presence of inactivating mutations in the VHL gene in most cases, and by infrequent somatic mutations in known cancer genes. To determine further the genetics of ccRCC, we have sequenced 101 cases through 3,544 protein-coding genes. Here we report the identification of inactivating mutations in two genes...
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