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Article

Epigenetic regulation in RCC: opportunities for therapeutic intervention?

Nature reviews. Urology - 17 Jan 2012

Larkin James, Goh Xin Yi, Vetter Marcus, Pickering Lisa, Swanton Charles

Abstract excerpt

Renal cell carcinoma (RCC) is a constellation of malignancies of different histological subtypes arising from the renal parenchyma. The clear cell histological subtype (ccRCC) accounts for around 75% of RCCs and is characterized by distinct genetic abnormalities, of which the loss of function of the von Hippel-Lindau (VHL) tumor suppressor gene is the most common. Inactivation of other tumor suppressor genes such...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

Identifiers

PMID: 22249190
DOI: 10.1038/nrurol.2011.236

Genes

PBRM1
SETD2
VHL

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 3 Sept 2026.

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