Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

The epigenetic landscape of renal cancer.

Nature reviews. Nephrology - 1 Jan 2017

Morris Mark R, Latif Farida

Abstract excerpt

The majority of kidney cancers are associated with mutations in the von Hippel-Lindau gene and a small proportion are associated with infrequent mutations in other well characterized tumour-suppressor genes. In the past 15 years, efforts to uncover other key genes involved in renal cancer have identified many genes that are dysregulated or silenced via epigenetic mechanisms, mainly through methylation of promoter...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to PBRM1 gene
Share to SETD2 gene
Share to Histones

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Epigenesis, Genetic

Share to DNA Methylation

Share to Kidney Neoplasms

Share to Mutation

Share to Signal Transduction

Source

Identifiers

PMID: 27890923
DOI: 10.1038/nrneph.2016.168

Genes

BAP1
PBRM1
SETD2

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 3 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

The epigenetic landscape of renal cancer.PMID 27890923Read ↗

Epigenetic modifiers: activities in renal cell carcinoma.Semantic proximity Read ↗

The Epigenetics of Renal Cell Tumors: from Biology to BiomarkersSemantic proximity Read ↗

Epigenetic regulation in RCC: opportunities for therapeutic intervention?Semantic proximity Read ↗

Epigenome Aberrations: Emerging Driving Factors of the Clear Cell Renal Cell Carcinoma.Semantic proximity Read ↗

Epigenetics in renal cell cancer: mechanisms and clinical applications.Semantic proximity Read ↗

An Overview of Epigenetics in Clear Cell Renal Cell CarcinomaSemantic proximity Read ↗

PBRM1 and BAP1 as novel targets for renal cell carcinoma.Semantic proximity Read ↗

Genetic and epigenetic profiling indicates the proximal tubule origin of renal cancers in end-stage renal disease.Semantic proximity Read ↗

DNA methylation profiling distinguishes histological subtypes of renal cell carcinomaSemantic proximity Read ↗

DNA Methylation Dysfunction in Chronic Kidney DiseaseSemantic proximity Read ↗

PBRM1 acts as a p53 lysine-acetylation reader to suppress renal tumor growth.Semantic proximity Read ↗

BAP1, PBRM1 and SETD2 in clear-cell renal cell carcinoma: molecular diagnostics and possible targets for personalized therapies.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.