Article
Clinical and pathologic impact of select chromatin-modulating tumor suppressors in clear cell renal cell carcinoma.
European urology - 1 May 2013
Hakimi A Ari, Chen Ying-Bei, Wren James, Gonen Mithat, Abdel-Wahab Omar, Heguy Adriana, Liu Han, Takeda Shugaku, Tickoo Satish K, Reuter Victor E, Voss Martin H, Motzer Robert J, Coleman Jonathan A, Cheng Emily H, Russo Paul, Hsieh James J
Abstract excerpt
BACKGROUND: Historically, VHL was the only frequently mutated gene in clear cell renal cell carcinoma (ccRCC), with conflicting clinical relevance. Recent sequencing efforts have identified several novel frequent mutations of histone modifying and chromatin remodeling genes in ccRCC including PBRM1, SETD2, BAP1, and KDM5C. PBRM1, SETD2, and BAP1 are located in close proximity to VHL within a commonly lost...
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