Article
Epigenetic modifiers: activities in renal cell carcinoma.
Nature reviews. Urology - 1 Oct 2018
de Cubas Aguirre A, Rathmell W Kimryn
Abstract excerpt
Renal cell carcinomas (RCCs) are a diverse set of malignancies that have recently been shown to harbour mutations in a number of chromatin modifier genes - including PBRM1, SETD2, BAP1, KDM5C, KDM6A, and MLL2 - through high-throughput sequencing efforts. Current research focuses on understanding the biological activities that chromatin modifiers employ to suppress tumorigenesis and on developing clinical...
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