Article
Proteogenomic, Epigenetic, and Clinical Implications of Recurrent Aberrant Splice Variants in Clear Cell Renal Cell Carcinoma.
European urology - 1 Oct 2022
Chang Andrew, Chakiryan Nicholas H, Du Dongliang, Stewart Paul A, Zhang Yonghong, Tian Yijun, Soupir Alex C, Bowers Kiah, Fang Bin, Morganti Ashley, Teer Jamie K, Kim Youngchul, Spiess Philippe E, Chahoud Jad, Noble Jerald D, Putney Ryan M, Berglund Anders E, Robinson Timothy J, Koomen John M, Wang Liang, Manley Brandon J
Abstract excerpt
BACKGROUND: Alternative mRNA splicing can be dysregulated in cancer, resulting in the generation of aberrant splice variants (SVs). Given the paucity of actionable genomic mutations in clear cell renal cell carcinoma (ccRCC), aberrant SVs may be an avenue to novel mechanisms of pathogenesis. OBJECTIVE: To identify and characterize aberrant SVs enriched in ccRCC. DESIGN, SETTING, AND PARTICIPANTS: Using RNA-seq...
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