Article
Exome sequencing identifies frequent mutation of the SWI/SNF complex gene PBRM1 in renal carcinoma.
Nature - 27 Jan 2011
Varela Ignacio, Tarpey Patrick, Raine Keiran, Huang Dachuan, Ong Choon Kiat, Stephens Philip, Davies Helen, Jones David, Lin Meng-Lay, Teague Jon, Bignell Graham, Butler Adam, Cho Juok, Dalgliesh Gillian L, Galappaththige Danushka, Greenman Chris, Hardy Claire, Jia Mingming, Latimer Calli, Lau King Wai, Marshall John, McLaren Stuart, Menzies Andrew, Mudie Laura, Stebbings Lucy, Largaespada David A, Wessels L F A, Richard Stephane, Kahnoski Richard J, Anema John, Tuveson David A, Perez-Mancera Pedro A, Mustonen Ville, Fischer Andrej, Adams David J, Rust Alistair, Chan-on Waraporn, Subimerb Chutima, Dykema Karl, Furge Kyle, Campbell Peter J, Teh Bin Tean, Stratton Michael R, Futreal P Andrew
Abstract excerpt
The genetics of renal cancer is dominated by inactivation of the VHL tumour suppressor gene in clear cell carcinoma (ccRCC), the commonest histological subtype. A recent large-scale screen of ∼3,500 genes by PCR-based exon re-sequencing identified several new cancer genes in ccRCC including UTX (...
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