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Mechanisms of inhibition of endothelial cell migration by taxanes

24 Oct 2013

Abstract excerpt

Several antiangiogenic mechanisms have been proposed for the widely-used cancer chemotherapeutic drugs taxotere (docetaxel) and taxol (paclitaxel), but none has been definitively identified. We analyzed their effects at a range of concentrations on migration and mitosis of human umbilical vein endothelial cells (HUVECs) on microtubule and focal adhesion morphology and microtubule dynamic instability during...

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PMID: 24155271
DOI: 10.1002/cm.21153

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