Article
The Elephant in the Room: The Role of Microtubules in Cancer.
Advances in experimental medicine and biology - 1 Jan 2017
Cirillo Luca, Gotta Monica, Meraldi Patrick
Abstract excerpt
Microtubules are the backbone of all eukaryotic cells cytoskeleton. Their dynamic behaviour constitutes the basis for many biological processes such as cellular motility, cytoplasmic transport and cell division. Some the most effective chemotherapeutics, such as the taxanes, are microtubule interfering drugs. Moreover, many studies suggest that microtubule dynamics are altered in cancer cell divisions and linked...
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