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Microtubules and Cell Division: Potential Pharmacological Targets in Cancer Therapy

31 Jul 2023

Abstract excerpt

Microtubules are a well-known target in cancer chemotherapy because of their critical role in cell division. Chromosome segregation during mitosis depends on the establishment of the mitotic spindle apparatus through microtubule dynamics. The disruption of microtubule dynamics through the stabilization or destabilization of microtubules results in the mitotic arrest of the cells. Microtubule-targeted drugs, which...

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PMID: 37519203
DOI: 10.2174/1389450124666230731094837

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