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Article

Microtubule Active Agents: Beyond the Taxane Frontier

14 Nov 2008

Abstract excerpt

Microtubules are essential to cell transport, signaling, and mitosis. An increasing range of anticancer drugs interferes with the normal formation and function of microtubules. Vinca alkaloids act as microtubule destabilizers and the taxanes act as microtubule stabilizers. Taxanes are widely used cytotoxic agents that are active in a range of solid tumor malignancies and are routinely used in a variety of...

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PMID: 19010832
DOI: 10.1158/1078-0432.ccr-08-0169

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