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Article

Microtubule Dynamics Control Tail Retraction in Migrating Vascular Endothelial Cells

10 Oct 2013

Abstract excerpt

Drugs that target microtubules are potent inhibitors of angiogenesis, but their mechanism of action is not well understood. To explore this, we treated human umbilical vein endothelial cells with paclitaxel, vinblastine, and colchicine and measured the effects on microtubule dynamics and cell motility. In general, lower drug concentrations suppressed microtubule dynamics and inhibited cell migration whereas...

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PMID: 24107446
DOI: 10.1158/1535-7163.mct-13-0401

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