Article
Impact of mutations in Toll-like receptor pathway genes on esophageal carcinogenesis.
PLoS genetics - 1 May 2017
Fels Elliott Daffolyn Rachael, Perner Juliane, Li Xiaodun, Symmons Martyn F, Verstak Brett, Eldridge Matthew, Bower Lawrence, O'Donovan Maria, Gay Nick J, Fitzgerald Rebecca C
Abstract excerpt
Esophageal adenocarcinoma (EAC) develops in an inflammatory microenvironment with reduced microbial diversity, but mechanisms for these influences remain poorly characterized. We hypothesized that mutations targeting the Toll-like receptor (TLR) pathway could disrupt innate immune signaling and promote a microenvironment that favors tumorigenesis. Through interrogating whole genome sequencing data from 171 EAC...
Read the complete abstract on PubMedTopics
Share this publication in a Topic to start or enrich a Post.