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Article

Multiple Roles of Toll-Like Receptor 4 in Colorectal Cancer

15 Jul 2014

Abstract excerpt

Toll-like receptor (TLR) signaling has been implicated in the inflammatory responses in intestinal epithelial cells (IECs). Such inflammatory signals mediate complex interactions between commensal bacteria and TLRs and are required for IEC proliferation, immune response, repair, and homeostasis. The upregulation of certain TLRs in colorectal cancer (CRC) tissues suggests that TLRs may play an essential role in...

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PMID: 25076949
DOI: 10.3389/fimmu.2014.00334

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