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Article

Microbially driven TLR5-dependent signaling governs distal malignant progression through tumor-promoting inflammation.

Cancer cell - 12 Jan 2015

Rutkowski Melanie R, Stephen Tom L, Svoronos Nikolaos, Allegrezza Michael J, Tesone Amelia J, Perales-Puchalt Alfredo, Brencicova Eva, Escovar-Fadul Ximena, Nguyen Jenny M, Cadungog Mark G, Zhang Rugang, Salatino Mariana, Tchou Julia, Rabinovich Gabriel A, Conejo-Garcia Jose R

Abstract excerpt

The dominant TLR5(R392X) polymorphism abrogates flagellin responses in >7% of humans. We report that TLR5-dependent commensal bacteria drive malignant progression at extramucosal locations by increasing systemic IL-6, which drives mobilization of myeloid-derived suppressor cells (MDSCs). Mechanistically, expanded granulocytic MDSCs cause γδ lymphocytes in TLR5-responsive tumors to secrete galectin-1, dampening...

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Identifiers

PMID: 25533336
DOI: 10.1016/j.ccell.2014.11.009
PMCID: PMC4293269

Genes

TLR5

Variants

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