Article

Blockade of C5aR1 resets M1 via gut microbiota-mediated PFKM stabilization in a TLR5-dependent manner

2023-11-08

Abstract excerpt

<title>Abstract</title> <p>Background: Targeting C5aR1 modulates the function of infiltrated immune cells including tumor-associated macrophages (TAMs). The gut microbiome plays a pivotal role in colorectal cancer (CRC) tumorigenesis and development through TAM education. However, whether and how the gut flora is involved in C5aR1 inhibition-mediated TAMs remains unclear. <h4>Methods:</h4> Genetic deletion C5ar1...

Topics

Open a Topic to create a Post that cites this publication.

Identifiers and source

Literature Corpus work: 71fe1315-7655-59e3-9881-e988a2e84bd2
DOI: 10.21203/rs.3.rs-3421751/v1

Open publication

Related research

Semantic proximity does not establish scientific evidence.

Click a neighbor to travelStep 1 · 12 closest

Blockade of C5aR1 resets M1 via gut microbiota-mediated PFKM stabilization in a TLR5-dependent mannerDOI 10.21203/rs.3.rs-3421751/v1Read

C5aR1 promotes the progression of colorectal cancer by EMT and activating Wnt/β-catenin pathwaySemantic proximity Read

Acetoacetate suppresses colon cancer via an MR1-MAIT axisSemantic proximity Read

Establishment of a Gene Expression Signature for Colitis-Associated Colorectal Cancer to Assess Cancer-Promoting Effects of Standard IBD TreatmentsSemantic proximity Read

Advancements of Macrophages Involvement in Pathological Progression of Colitis-Associated Colorectal Cancer and Associated Pharmacological InterventionsSemantic proximity Read

ANKRD22 Participates in Pro-inflammatory Activities of Macrophages in the Tumor Microenvironment of Colon CancerSemantic proximity Read

Blockade of IL-6 inhibits tumor immune evasion and improves anti–PD-1 immunotherapySemantic proximity Read

Blockade of C5a receptor unleashes tumor-associated macrophage antitumor response and enhances CXCL9-dependent CD8+ T cell activitySemantic proximity Read

Functional TLR5 genetic variants affect human colorectal cancer survival.Semantic proximity Read

ACSL4 knockdown inhibits colorectal cancer progression through stimulating anti-tumor immunitySemantic proximity Read

Innate immune receptor C5aR1 regulates cancer cell fate and can be targeted to improve radiotherapy in tumours with immunosuppressive microenvironmentsSemantic proximity Read

ACB1801 enhances tumor immunogenicity by targeting glycolysis/ferroptosis vulnerability and activating STAT1-signaling to overcome anti-PD-1 resistance in MSS colorectal cancerSemantic proximity Read

The FBW7-MCL-1 axis is key in M1 and M2 macrophage-related colon cancer cell progression: validating the immunotherapeutic value of targeting PI3Kγ.Semantic proximity Read