Article
Genetic control of renal tumorigenesis by the mouse Rtm1 locus.
BMC genomics - 22 Oct 2013
Jensen José Ricardo, Galvan Antonella, Borrego Andrea, Cabrera Wafa Hanna Koury, Ribeiro Orlando Garcia, Starobinas Nancy, De Franco Marcelo, Colecchia Maurizio, Bertolotti Alessia, Dragani Tommaso Antonio, Ibañez Olga Célia Martinez
Abstract excerpt
BACKGROUND: The genetic basis of susceptibility to renal tumorigenesis has not yet been established in mouse strains. Mouse lines derived by bidirectional phenotypic selection on the basis of their maximal (AIRmax) or minimal (AIRmin) acute inflammatory responsiveness differ widely in susceptibility to spontaneous and urethane-induced renal tumorigenesis. To map the functional loci modulating renal tumor...
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