Article
Genetic heterogeneity of inflammatory response and skin tumorigenesis in phenotypically selected mouse lines.
Cancer letters - 1 Sept 2010
Galvan Antonella, Vorraro Francisca, Cabrera Wafa Hanna Koury, Ribeiro Orlando Garcia, Pazzaglia Simonetta, Mancuso Mariateresa, Zolin Anna, Milani Silvano, Saran Anna, Ibañez Olga M, Dragani Tommaso A
Abstract excerpt
Non-inbred AIR (AIRmax, AIRmin) and Car (Car-S, Car-R) mouse lines were generated from the same eight inbred mice through bidirectional selective breeding for acute inflammatory response and for susceptibility to two-stage skin tumorigenesis, respectively. Because AIR lines also showed a differential predisposition to skin tumorigenesis and Car lines differed in the extent of inflammatory response, we carried out...
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