Mouse genome-wide association mapping needs linkage analysis to avoid false-positive Loci.

doi:10.1371/journal.pgen.1000331

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Article

Mouse genome-wide association mapping needs linkage analysis to avoid false-positive Loci.

PLoS genetics - 1 Jan 2009

Manenti Giacomo, Galvan Antonella, Pettinicchio Angela, Trincucci Gaia, Spada Elena, Zolin Anna, Milani Silvano, Gonzalez-Neira Anna, Dragani Tommaso A

Abstract excerpt

We carried out genome-wide association (GWA) studies in inbred mouse strains characterized for their lung tumor susceptibility phenotypes (spontaneous or urethane-induced) with panels of 12,959 (13K) or 138,793 (140K) single-nucleotide polymorphisms (SNPs). Above the statistical thresholds, we detected only SNP rs3681853 on Chromosome 5, two SNPs in the pulmonary adenoma susceptibility 1 (Pas1) locus, and SNP...

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Identifiers

PMID: 19132132
DOI: 10.1371/journal.pgen.1000331
PMCID: PMC2614123

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

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