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Article

Biological and clinical determinants shaping heterogeneity in mantle cell lymphoma

15 May 2024

Abstract excerpt

ABSTRACT: Mantle cell lymphoma (MCL) is an uncommon mature B-cell lymphoma that presents a clinical spectrum ranging from indolent to aggressive disease, with challenges in disease management and prognostication. MCL is characterized by significant genomic instability, affecting various cellular processes, including cell cycle regulation, cell survival, DNA damage response and telomere maintenance, NOTCH and...

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PMID: 38748869
DOI: 10.1182/bloodadvances.2023011763

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