Article
Genomic landscape and prognostic analysis of mantle cell lymphoma.
Cancer gene therapy - 1 Jun 2018
Yang Ping, Zhang Weilong, Wang Jing, Liu Yuanyuan, An Ran, Jing Hongmei
Abstract excerpt
To gain insight into the molecular pathogenesis of patients with mantle cell lymphoma (MCL), next-generation whole-exome sequencing of 16 MCL patients was performed. We identified recurrent mutations in genes that are well known to be functionally relevant in MCL, including ATM (37.5%), TP53 (31.3%), WHSC1 (31.3%), CCND1 (18.8%), NOTCH2 (6.3%), and CDKN2A (6.3%). We also identified somatic mutations in genes for...
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