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Genetic heterogeneity and prognostic impact of recurrent ANK2 and TP53 mutations in mantle cell lymphoma: a multi-centre cohort study.

Scientific reports - 7 Aug 2020

Jeong Seri, Park Yu Jin, Yun Woobin, Lee Seung-Tae, Choi Jong Rak, Suh Cheolwon, Jo Jae-Cheol, Cha Hee Jeong, Jeong Jee-Yeong, Chang HeeKyung, Cha Yoon Jin, Kim Hyerim, Park Min-Jeong, Song Wonkeun, Cho Eun-Hae, Jeong Eun-Goo, Lee Junnam, Park Yongmin, Lee Yong Seok, Kim Da Jung, Lee Ho Sup

Abstract excerpt

The molecular features of mantle cell lymphoma (MCL), including its increased incidence, and complex therapies have not been investigated in detail, particularly in East Asian populations. In this study, we performed targeted panel sequencing (TPS) and whole-exome sequencing (WES) to investigate the genetic alterations in Korean MCL patients. We obtained a total of 53 samples from MCL patients from five Korean...

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Identifiers

PMID: 32770099
DOI: 10.1038/s41598-020-70310-9
PMCID: PMC7414214

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