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Targeted genomic investigations in a population-based cohort of mantle cell lymphoma reveal novel clinically relevant targets.

Leukemia & lymphoma - 1 Nov 2021

Rodrigues Joana M, Porwit Anna, Hassan May, Ek Sara, Jerkeman Mats

Abstract excerpt

Mantle cell lymphoma (MCL) is an aggressive B-cell neoplasm that follows a heterogeneous clinical course. Recurrent mutations have been described, but their applicability in the clinical setting is currently limited. The main reasons are challenges in the sequencing of DNA retrieved from formalin-fixed tissue commonly used for tissue collection in clinical biobanks. In this study, we sequenced 77 samples from a...

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PMID: 34080947
DOI: 10.1080/10428194.2021.1933480

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