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Article

Stromal cell senescence augments haematopoietic cell fitness in clonal haematopoiesis.

Nature cell biology - 1 Aug 2026

Mistry Jayna J, Young Kira A, Navarro Figueredo Anna, Edun Gibran, Aguilar-Navarro Alicia G, Colom Díaz Patricia A, Telpoukhovskaia Maria, Fernández Maestre Inés, Cai Sheng F, Götze Katharina S, Tikhonova Anastasia N, Levine Ross L, Trowbridge Jennifer J

Abstract excerpt

Microenvironment remodelling impacts tumour growth and metastasis, but whether remodelling promotes pre-malignant clonal fitness remains unknown. Here, using single-cell RNA-sequencing of the bone-marrow microenvironment in a mouse model of DNMT3A-mutant clonal haematopoiesis (CH), we identify mesenchymal stromal cells (MSCs) in a molecular state of cellular senescence. Elevated bone-marrow MSC senescence is also...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

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Identifiers

PMID: 42562925
DOI: 10.1038/s41556-026-02025-4
PMCID: PMC13457089

Genes

MSC
DNMT3A
TNF

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 8 Sept 2026.

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