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Article

Regulation of hematopoietic stem cell aging by the small RhoGTPase Cdc42.

Experimental cell research - 10 Dec 2014

Geiger Hartmut, Zheng Yi

Abstract excerpt

Aging of stem cells might be the underlying cause of tissue aging in tissue that in the adult heavily rely on stem cell activity, like the blood forming system. Hematopoiesis, the generation of blood forming cells, is sustained by hematopoietic stem cells. In this review article, we introduce the canonical set of phenotypes associated with aged HSCs, focus on the novel aging-associated phenotype apolarity caused...

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Identifiers

PMID: 25220425
DOI: 10.1016/j.yexcr.2014.09.001
PMCID: PMC4427663

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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