Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Gene profiling reveals association between altered Wnt signaling and loss of T‐cell potential with age in human hematopoietic stem cells

30 May 2014

Abstract excerpt

Functional decline of the hematopoietic system occurs during aging and contributes to clinical consequences, including reduced competence of adaptive immunity and increased incidence of myeloid diseases. This has been linked to aging of the hematopoietic stem cell (HSC) compartment and has implications for clinical hematopoietic cell transplantation as prolonged periods of T-cell deficiency follow transplantation...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Hematopoietic Stem Cell Transplantation
Share to T-cell and B-cell Immunology
Share to Wnt/β-catenin signaling in development and cancer

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Source

Identifiers

PMID: 24889652
DOI: 10.1111/acel.12229

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 4 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Gene profiling reveals association between altered Wnt signaling and loss of T‐cell potential with age in human hematopoietic stem cellsPMID 24889652Read ↗

Cell intrinsic alterations underlie hematopoietic stem cell agingSemantic proximity Read ↗

Mechanisms and rejuvenation strategies for aged hematopoietic stem cellsSemantic proximity Read ↗

High Levels of Canonical Wnt Signaling Lead to Loss of Stemness and Increased Differentiation in Hematopoietic Stem Cells.Semantic proximity Read ↗

A canonical to non-canonical Wnt signalling switch in haematopoietic stem-cell ageing.Semantic proximity Read ↗

EGR1 dysregulation defines an inflammatory and leukemic program in cell trajectory of human-aged hematopoietic stem cells (HSC)Semantic proximity Read ↗

Aging hematopoietic stem cells decline in function and exhibit epigenetic dysregulation.Semantic proximity Read ↗

Deciphering the evolving niche interactome of human hematopoietic stem cells from ontogeny to agingSemantic proximity Read ↗

Oncostatin M is a Master Regulator of an Inflammatory Network in <i>Dnmt3a</i> -Mutant Hematopoietic Stem CellsSemantic proximity Read ↗

Wnt/Catenin Signaling in Adult Stem Cell Physiology and DiseaseSemantic proximity Read ↗

Identification of potential biomarkers for aging diagnosis of mesenchymal stem cells derived from the aged donorsSemantic proximity Read ↗

PLZF mutation alters mouse hematopoietic stem cell function and cell cycle progression.Semantic proximity Read ↗

Systemic deficits in lipid homeostasis promote aging-associated impairments in B cell progenitor developmentSemantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.