Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

WNT/beta-catenin signalling interrupts a senescence-induction cascade in human mesenchymal stem cells that restricts their expansion

20 Jan 2022

Abstract excerpt

Senescence, the irreversible cell cycle arrest of damaged cells, is accompanied by a deleterious pro-inflammatory senescence-associated secretory phenotype (SASP). Senescence and the SASP are major factors in aging, cancer, and degenerative diseases, and interfere with the expansion of adult cells in vitro, yet little is known about how to counteract their induction and deleterious effects. Paracrine signals are...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Corneal Surgery and Treatments
Share to Mesenchymal stem cell research
Share to Telomeres, Telomerase, and Senescence

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Source

Identifiers

PMID: 35048158
DOI: 10.1007/s00018-021-04035-x

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 8 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

WNT/beta-catenin signalling interrupts a senescence-induction cascade in human mesenchymal stem cells that restricts their expansionPMID 35048158Read ↗

Targeting cellular senescence to combat cancer and ageingSemantic proximity Read ↗

Cellular senescence: mechanisms and relevance to cancer and agingSemantic proximity Read ↗

Paracrine Senescence of Mesenchymal Stromal Cells Involves Inflammatory Cytokines and the NF-κB PathwaySemantic proximity Read ↗

Recent Advancement in Elimination Strategies and Potential Rejuvenation Targets of Senescence.Semantic proximity Read ↗

Stress-induced senescence in mesenchymal stem cells: Triggers, hallmarks, and current rejuvenation approachesSemantic proximity Read ↗

Cross-talk of inflammation and cellular senescence: a new insight into the occurrence and progression of osteoarthritisSemantic proximity Read ↗

Paracrine roles of cellular senescence in promoting tumourigenesisSemantic proximity Read ↗

Cellular Senescence: The Trojan Horse in Chronic Lung DiseasesSemantic proximity Read ↗

Potential Regulators of the Senescence-Associated Secretory Phenotype During Senescence and Aging.Semantic proximity Read ↗

Application of mesenchymal stem cells for anti-senescence and clinical challengesSemantic proximity Read ↗

Deconstructing replicative senescence heterogeneity of human mesenchymal stem cells at single cell resolution reveals therapeutically targetable senescent cell sub-populationsSemantic proximity Read ↗

Mesenchymal Stem Cell Senescence during Aging:From Mechanisms to Rejuvenation StrategiesSemantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.