Article
Arginine methylation modulates autophagic degradation of PGL granules in C. elegans.
Molecular cell - 7 Nov 2013
Li Sihui, Yang Peiguo, Tian E, Zhang Hong
Abstract excerpt
The selective degradation of intracellular components by autophagy involves sequential interactions of the cargo with a receptor, which also binds the autophagosomal protein Atg8 and a scaffold protein. Here, we demonstrated that mutations in C. elegans epg-11, which encodes an arginine methyltransferase homologous to PRMT1, cause the defective removal of PGL-1 and PGL-3 (cargo)-SEPA-1 (receptor) complexes, known...
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