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Article

The WD40 repeat PtdIns(3)P-binding protein EPG-6 regulates progression of omegasomes to autophagosomes.

Developmental cell - 16 Aug 2011

Lu Qun, Yang Peiguo, Huang Xinxin, Hu Wanqiu, Guo Bin, Wu Fan, Lin Long, Kovács Attila L, Yu Li, Zhang Hong

Abstract excerpt

PtdIns(3)P plays critical roles in the autophagy pathway. However, little is known about how PtdIns(3)P effectors act with autophagy proteins in autophagosome formation. Here we identified an essential autophagy gene in C. elegans, epg-6, which encodes a WD40 repeat-containing protein with PtdIns(3)P-binding activity. EPG-6 directly interacts with ATG-2. epg-6 and atg-2 regulate progression of omegasomes to...

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PMID: 21802374
DOI: 10.1016/j.devcel.2011.06.024

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