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Article

Genetic analysis of lysosomal trafficking in Caenorhabditis elegans.

Molecular biology of the cell - 1 Jul 2005

Hermann Greg J, Schroeder Lena K, Hieb Caroline A, Kershner Aaron M, Rabbitts Beverley M, Fonarev Paul, Grant Barth D, Priess James R

Abstract excerpt

The intestinal cells of Caenorhabditis elegans embryos contain prominent, birefringent gut granules that we show are lysosome-related organelles. Gut granules are labeled by lysosomal markers, and their formation is disrupted in embryos depleted of AP-3 subunits, VPS-16, and VPS-41. We define a class of gut granule loss (glo) mutants that are defective in gut granule biogenesis. We show that the glo-1 gene...

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Identifiers

PMID: 15843430
DOI: 10.1091/mbc.e05-01-0060
PMCID: PMC1165410

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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