Article
glo-3, a novel Caenorhabditis elegans gene, is required for lysosome-related organelle biogenesis.
Genetics - 1 Oct 2008
Rabbitts Beverley M, Ciotti Marcela K, Miller Natalie E, Kramer Maxwell, Lawrenson Andrea L, Levitte Steven, Kremer Susan, Kwan Elizabeth, Weis Allison M, Hermann Greg J
Abstract excerpt
Gut granules are specialized lysosome-related organelles that act as sites of fat storage in Caenorhabditis elegans intestinal cells. We identified mutations in a gene, glo-3, that functions in the formation of embryonic gut granules. Some glo-3(-) alleles displayed a complete loss of embryonic gut granules, while other glo-3(-) alleles had reduced numbers of gut granules. A subset of glo-3 alleles led to...
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