Article
The scaffold protein EPG-7 links cargo-receptor complexes with the autophagic assembly machinery.
The Journal of cell biology - 1 Apr 2013
Lin Long, Yang Peiguo, Huang Xinxin, Zhang Hui, Lu Qun, Zhang Hong
Abstract excerpt
The mechanism by which protein aggregates are selectively degraded by autophagy is poorly understood. Previous studies show that a family of Atg8-interacting proteins function as receptors linking specific cargoes to the autophagic machinery. Here we demonstrate that during Caenorhabditis elegans embryogenesis, epg-7 functions as a scaffold protein mediating autophagic degradation of several protein aggregates,...
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