Article
LYSMD proteins promote activation of Rab32-family GTPases for lysosome-related organelle biogenesis.
The Journal of cell biology - 7 Oct 2024
Li Jinglin, Yin Qiuyuan, Xuan Nan, Gan Qiwen, Liu Chaolian, Zhang Qian, Yang Mei, Yang Chonglin
Abstract excerpt
Lysosome-related organelles (LROs) are specialized lysosomes with cell type-specific roles in organismal homeostasis. Dysregulation of LROs leads to many human disorders, but the mechanisms underlying their biogenesis are not fully understood. Here, we identify a group of LYSMD proteins as evolutionarily conserved regulators of LROs. In Caenorhabditis elegans, mutations of LMD-2, a LysM domain-containing protein,...
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