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Article

The conserved autoimmune-disease risk gene TMEM39A regulates lysosome dynamics.

Proceedings of the National Academy of Sciences of the United States of America - 9 Feb 2021

Luo Shuo, Wang Xin, Bai Meirong, Jiang Wei, Zhang Zhe, Chen Yifan, Ma Dengke K

Abstract excerpt

TMEM39A encodes an evolutionarily conserved transmembrane protein and carries single-nucleotide polymorphisms associated with increased risk of major human autoimmune diseases, including multiple sclerosis. The exact cellular function of TMEM39A remains not well understood. Here, we report that TMEM-39, the sole Caenorhabditis elegans (C. elegans) ortholog of TMEM39A, regulates lysosome distribution and...

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Identifiers

PMID: 33531362
DOI: 10.1073/pnas.2011379118
PMCID: PMC8017986

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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