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Article

Lysine desuccinylase SIRT5 binds to cardiolipin and regulates the electron transport chain.

The Journal of biological chemistry - 16 Jun 2017

Zhang Yuxun, Bharathi Sivakama S, Rardin Matthew J, Lu Jie, Maringer Katherine V, Sims-Lucas Sunder, Prochownik Edward V, Gibson Bradford W, Goetzman Eric S

Abstract excerpt

SIRT5 is a lysine desuccinylase known to regulate mitochondrial fatty acid oxidation and the urea cycle. Here, SIRT5 was observed to bind to cardiolipin via an amphipathic helix on its N terminus. In vitro, succinyl-CoA was used to succinylate liver mitochondrial membrane proteins. SIRT5 largely reversed the succinyl-CoA-driven lysine succinylation. Quantitative mass spectrometry of SIRT5-treated membrane...

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Share to Cardiolipins
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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Share to Mitochondria, Liver

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Source

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Identifiers

PMID: 28458255
DOI: 10.1074/jbc.M117.785022
PMCID: PMC5473227

Genes

SIRT5

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 4 Sept 2026.

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