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Lysine succinylation, the metabolic bridge between cancer and immunity

1 Dec 2022

Abstract excerpt

Lysine succinylation is a naturally occurring post-translational modification (PTM) that regulates the stability and function of proteins. It can be regulated by enzymes such as SIRT5 and SIRT7. Recently, the effect and significance of lysine succinylation in cancer and its implication in immunity have been extensively explored. Lysine succinylation is involved in the malignant phenotype of cancer cells. Abnormal...

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PMID: 37554179
DOI: 10.1016/j.gendis.2022.10.028

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