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Article

SIRT5 stabilizes mitochondrial glutaminase and supports breast cancer tumorigenesis

16 Dec 2019

Abstract excerpt

Significance The mitochondrial enzyme glutaminase (GLS) is frequently up-regulated in cancer cells, and a GLS-selective inhibitor is being evaluated in clinical trials. Previous screens identified succinylated lysine residues on GLS, but the functional consequences of these posttranslational modifications have remained unclear. Here, we report that the mitochondrial desuccinylase SIRT5 stabilizes GLS. Both GLS...

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PMID: 31843902
DOI: 10.1073/pnas.1911954116

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