Article

SIRT5-mediated desuccinylation prevents mitochondrial dysfunction in Alveolar epithelial cells senescence and Pulmonary fibrosis

2024-07-15

Abstract excerpt

<title>Abstract</title> <p>Background Senescence of alveolar epithelial cells (AEC) is a key event in the occurrence and development of Idiopathic pulmonary fibrosis (IPF). The pathogenic mechanisms that underlie the effects of AEC senescence remain largely unexplained. Some age-related diseases have an etiology that is related to mitochondrial dysfunction induced by excessive lysine succinylation (Ksucc). Excess...

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Literature Corpus work: fe1f879b-0a60-526e-b9fb-f00998d511b5
DOI: 10.21203/rs.3.rs-4594800/v1

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