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Article

Caenorhabditis elegans RSD-2 and RSD-6 promote germ cell immortality by maintaining small interfering RNA populations.

Proceedings of the National Academy of Sciences of the United States of America - 14 Oct 2014

Sakaguchi Aisa, Sarkies Peter, Simon Matt, Doebley Anna-Lisa, Goldstein Leonard D, Hedges Ashley, Ikegami Kohta, Alvares Stacy M, Yang Liwei, LaRocque Jeannine R, Hall Julie, Miska Eric A, Ahmed Shawn

Abstract excerpt

Germ cells are maintained in a pristine non-aging state as they proliferate over generations. Here, we show that a novel function of the Caenorhabditis elegans RNA interference proteins RNAi spreading defective (RSD)-2 and RSD-6 is to promote germ cell immortality at high temperature. rsd mutants cultured at high temperatures became progressively sterile and displayed loss of small interfering RNAs (siRNAs) that...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Identifiers

PMID: 25258416
DOI: 10.1073/pnas.1406131111
PMCID: PMC4205660

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 5 Sept 2026. Manifest publication-graph-cohort-2026-09-05.1.

Source receipt: pubmed, retrieved 5 Sept 2026.

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