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Article

METT-10, a putative methyltransferase, inhibits germ cell proliferative fate in Caenorhabditis elegans.

Genetics - 1 Sept 2009

Dorsett Maia, Westlund Bethany, Schedl Tim

Abstract excerpt

Germ-line stem cells are unique because they either self-renew through mitosis or, at a certain frequency, switch to meiosis and produce gametes. The switch from proliferation to meiosis is tightly regulated, and aberrations in switching result in either too little or too much proliferation. To understand the genetic basis of this regulation, we characterized loss-of-function mutations and a novel tumorous allele...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Identifiers

PMID: 19596901
DOI: 10.1534/genetics.109.105270
PMCID: PMC2746148

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