Article
Translesion synthesis of O4-alkylthymidine lesions in human cells.
Nucleic acids research - 2 Nov 2016
Wu Jun, Li Lin, Wang Pengcheng, You Changjun, Williams Nicole L, Wang Yinsheng
Abstract excerpt
Environmental exposure, endogenous metabolism and cancer chemotherapy can give rise to alkylation of DNA, and the resulting alkylated thymidine (alkyldT) lesions were found to be poorly repaired and persistent in mammalian tissues. Unrepaired DNA lesions may compromise genomic integrity by inhibiting DNA replication and inducing mutations in these processes. In this study, we explored how eight O4-alkyldT...
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