Cytotoxic and mutagenic properties of alkyl phosphotriester lesions in Escherichia coli cells.

doi:10.1093/nar/gky140

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Article

Cytotoxic and mutagenic properties of alkyl phosphotriester lesions in Escherichia coli cells.

Nucleic acids research - 4 May 2018

Wu Jiabin, Wang Pengcheng, Wang Yinsheng

Abstract excerpt

Exposure to many endogenous and exogenous agents can give rise to DNA alkylation, which constitutes a major type of DNA damage. Among the DNA alkylation products, alkyl phosphotriesters have relatively high frequencies of occurrence and are resistant to repair in mammalian tissues. However, little is known about how these lesions affect the efficiency and fidelity of DNA replication in cells or how the...

Topics

Alkylation
DNA Damage
DNA Repair
DNA Replication
DNA, Bacterial
DNA-Directed DNA Polymerase
Escherichia coli
Escherichia coli Proteins
Mutagenesis
Mutation
O(6)-Methylguanine-DNA Methyltransferase
Stereoisomerism
Transcription Factors

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Identifiers

PMID: 29514270
DOI: 10.1093/nar/gky140
PMCID: PMC5934668

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