Article
Cytotoxic and mutagenic properties of O4-alkylthymidine lesions in Escherichia coli cells.
Nucleic acids research - 15 Dec 2015
Wang Pengcheng, Amato Nicholas J, Zhai Qianqian, Wang Yinsheng
Abstract excerpt
Due to the abundant presence of alkylating agents in living cells and the environment, DNA alkylation is generally unavoidable. Among the alkylated DNA lesions, O(4)-alkylthymidine (O(4)-alkyldT) are known to be highly mutagenic and persistent in mammalian tissues. Not much is known about how the structures of the alkyl group affect the repair and replicative bypass of the O(4)-alkyldT lesions, or how the latter...
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