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Article

Analysis of Drosophila glucuronyl C5-epimerase: implications for developmental roles of heparan sulfate sulfation compensation and 2-O-sulfated glucuronic acid.

The Journal of biological chemistry - 29 Nov 2013

Dejima Katsufumi, Takemura Masahiko, Nakato Eriko, Peterson Jesse, Hayashi Yoshiki, Kinoshita-Toyoda Akiko, Toyoda Hidenao, Nakato Hiroshi

Abstract excerpt

During the biosynthesis of heparan sulfate (HS), glucuronyl C5-epimerase (Hsepi) catalyzes C5-epimerization of glucuronic acid (GlcA), converting it to iduronic acid (IdoA). Because HS 2-O-sulfotransferase (Hs2st) shows a strong substrate preference for IdoA over GlcA, C5-epimerization is required for normal HS sulfation. However, the physiological significance of C5-epimerization remains elusive. To understand...

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Identifiers

PMID: 24133213
DOI: 10.1074/jbc.M113.499269
PMCID: PMC3843053

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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