Article
Analysis of Drosophila glucuronyl C5-epimerase: implications for developmental roles of heparan sulfate sulfation compensation and 2-O-sulfated glucuronic acid.
The Journal of biological chemistry - 29 Nov 2013
Dejima Katsufumi, Takemura Masahiko, Nakato Eriko, Peterson Jesse, Hayashi Yoshiki, Kinoshita-Toyoda Akiko, Toyoda Hidenao, Nakato Hiroshi
Abstract excerpt
During the biosynthesis of heparan sulfate (HS), glucuronyl C5-epimerase (Hsepi) catalyzes C5-epimerization of glucuronic acid (GlcA), converting it to iduronic acid (IdoA). Because HS 2-O-sulfotransferase (Hs2st) shows a strong substrate preference for IdoA over GlcA, C5-epimerization is required for normal HS sulfation. However, the physiological significance of C5-epimerization remains elusive. To understand...
Topics
- Animals
- Carbohydrate Epimerases
- Drosophila
- Drosophila Proteins
- Fibroblast Growth Factors
- Gene Expression Regulation, Developmental
- Glucuronates
- Glucuronic Acid
- Heparitin Sulfate
- Iduronic Acid
- Longevity
- Mutagenesis, Site-Directed